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15:13:19

Medical Xpress: Particular Sorts Of Graft-versus-host Condition Could Raise Danger Of Fatality, Researcher Shares

Their study appeared in the May issue of Biology of Blood and Marrow Transplantation, the official journal of the American Society for Blood and Marrow Transplantation . GVHD is a complication that can occur when a transplant patient receives stem cells or bone marrow from a donor. The transplanted cells regard the recipient's body as foreign and attack, causing symptoms ranging from nausea and skin rashes to fatigue and pain. Patients with GVHD are prescribed drugs to suppress their immune system to counteract the disease. The researchers studied data from 567 patients to determine if the characteristics and symptoms of chronic GVHD were associated with major clinical outcomes, such as quality of life and death. They looked specifically at the site of gastrointestinal tract involvement and liver abnormalities. "We found important differences in outcomes in relation to gastrointestinal and liver involvement," Pidala said. "Those with elevated bilirubin (a substance in bile) levels, higher gastrointestinal scores, or lower gastrointestinal involvement had an increased risk of death under current treatment approaches." The authors concluded that their findings will help physicians better define a patient's risk of complications and death after chronic GVHD diagnosis and treatment. 19 hours ago 0 Groundbreaking study that may change transplant practices Nov 20, 2012 Researchers from John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's 50 best cancer centers, played an important role in a study published in the New England Journal of Medicine on Oct ... No survival advantage with peripheral blood stem cells versus bone marrow Oct 19, 2012 (Medical Xpress)Claudio Anasetti, M.D., chair of the Department of Blood & Marrow Transplant at Moffitt Cancer Center, and colleagues from 47 research sites in the Blood and Marrow Transplant Clinical Trials Network conducted ... B cell survival holds key to chronic graft vs. host disease Aug 16, 2012 Leukemia and lymphoma patients who receive life-saving stem cell or bone marrow transplants often experience chronic side effects that significantly decrease quality of life, can last a lifetime, and ultimately affect their ... Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant Oct 21, 2011 A University of Michigan Health System-led team of researchers has found a biomarker they believe can help rapidly identify one of the most serious complications in patients with leukemia, lymphoma and other blood disorders ... Bone marrow and blood stem cell transplant survival rates equal, when donor is unrelated to patient Dec 12, 2011 Patients who receive a blood stem cell transplant from a donor outside of their family to treat leukemia and other blood diseases are more likely to have graft failure but less likely to experience graft-versus-host disease, ... Recommended for you Norovirus in food outlets to be mapped for first time 42 minutes ago The University of Liverpool is leading a 2 million Food Standards Agency (FSA) project to map the occurrence of norovirus in food premises and industry workers. Impact of whooping cough vaccination revealed 1 hour ago The most comprehensive study to date of the family of bacteria that causes whooping cough points to more effective vaccine strategies and reveals surprising findings about the bacteria's origin and evolution. The new results ... Saudi announces 11 new MERS infections 5 hours ago Saudi Arabia on Wednesday announced 11 new cases of MERS, including a 13-year-old child, as its acting health minister vowed to keep the public better informed on the coronavirus. Scientists identify a new variant of Ebola virus in Guinea 21 hours ago In an article which appeared in The New England journal of Medicine on 16 April, researchers from Inserm (Jean Merieux-Inserm BSL-4 Laboratory, Lyon) and the Institut Pasteur have published their initia ... Greece reports 1st MERS case, patient critical Apr 22, 2014 Greece has recorded its first case of the potentially fatal respiratory disease known as MERS, and the patient is in critical condition. Scientists link environmental, disease data to help combat malaria in Ethiopia Apr 22, 2014 Dealing with malaria is a fact of life for more than 91 million Ethiopians. Each year four to five million contract malaria, one of the biggest health problems in this poor country.
For the original version including any supplementary images or video, visit http://medicalxpress.com/news/2013-06-graft-versus-host-disease-death.html


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